Circulating long chain acylcarnitines and outcomes in diabetic heart failure: an HF-ACTION clinical trial substudy.

In analyses of baseline metabolite factors with change in pVO 2 between baseline and three months , no factor was significant nominally nor after FDR adjustment for multiple comparisons (Additional file 2 : Table S1), although factor 8 showed a trend for significance (nominal p = 0.07) for baseline levels associated with change in pVO 2 .

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In these exploratory analyses, we found that there was a trend toward significance with factor 5 levels changing to a lesser extent in participants with DM after exercise training (mean ∆ 0.090, p = 0.23) than in those without DM (mean ∆ 0.164, p = 0.08).

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