Efficacy and Safety of Peripherally Acting μ-Opioid Receptor Antagonist (PAMORAs) for the Management of Patients With Opioid-Induced Constipation: A Systematic Review.

Cureus · 2021 · PMC8339109 · PMID 34367804

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did not reach statistical significanceno p-value reported

In the same post hoc analysis, the improvements with 150 mg (20.0% of the sample) did not reach statistical significance [ 36 ].

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