Epigenetic Reprogramming of Tumor-Associated Fibroblasts in Lung Cancer: Therapeutic Opportunities.

To assess whether such “mechanical memory” was caused by changes in DNA methylation, we cultured pulmonary fibroblasts for 5 days on stiff hydrogels in the presence of TGF-β1, but found a modest reduction in global DNA methylation that did not reach statistical significance ( Figure 2 C) [ 32 ].

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