CRMH supplementation (4% w/w , 5 weeks) showed a trend to improve depression-like behavior in the FST in female Sprague Dawley (SD) rats at sea level but was depressant in males [ 39 ].
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Sex-Based Impact of Creatine Supplementation on Depressive Symptoms, Brain Serotonin and SSRI Efficacy in an Animal Model of Treatment-Resistant Depression.
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