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Sex-Based Impact of Creatine Supplementation on Depressive Symptoms, Brain Serotonin and SSRI Efficacy in an Animal Model of Treatment-Resistant Depression.

Int J Mol Sci · 2021 · PMC8348220 · PMID 34360959

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showed a trendno p-value reported
CRMH supplementation (4% w/w , 5 weeks) showed a trend to improve depression-like behavior in the FST in female Sprague Dawley (SD) rats at sea level but was depressant in males [ 39 ].

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