No effects of alcohol challenge on hepatic mRNA levels of Fgfr1 , which represents the preferred receptor of FGF21, were observed, while the down-regulation of its obligate co-receptor β-klotho ( Klb ) did not reach statistical significance ( Figure 2 B,C).
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Fibroblast Growth Factor 21 Response in a Preclinical Alcohol Model of Acute-on-Chronic Liver Injury.
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