Activated mast cells in skeletal muscle can be a potential mediator for cancer-associated cachexia.

38 Closer inspection of each of the genes showed significantly increased expression of TPSAB1 in the muscle of cachectic mice compared with the corresponding normal control mice ( Figure 1C ), and there was also an observed trend toward increased TPSB2 expression in early cachectic mice compared with control ( Figure 1D ).

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There were slight trends toward decreased mass in the EDL ( Figure 2F ) and SOL muscles ( Figure 2G ), although this did not reach statistical significance.

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