Individual <i>HLA-A, -B, -C</i>, and <i>-DRB1</i> Genotypes Are No Major Factors Which Determine COVID-19 Severity.

Front Immunol · 2021 · PMC8350391 · PMID 34381451

Europe PMC DOI

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closest p · 0.6× alpha

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showed a trendp=0.03actually significant

Among allotypes constituting the A02 supertype, individuals with HLA-A *02:01 showed a trend toward greater risk of symptomatic infections (p=0.03, p adj =0.12) and those with HLA-A *02:05 toward a greater risk of severe respiratory infections (p=0.04, p adj =0.18).

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a weak trendp=0.04actually significant

Homozygosity for HLA-A was associated with a weak trend for greater risk of having severe respiratory symptoms (OR 1.18, 95%-CI 1.01-1.37; p=0.04, p adj =0.16).

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