highly significantp<<10 − 300
For example, in the Wellcome Trust Case Control Consortium (WTCCC) dataset [ 13 ], the odds ratio ( OR ) of MS for individuals possessing one or more of these alleles is highly significant–for HLA-DRB1 * 15 : 01 ( OR = 3 . 24; p<<10 − 300 ); for HLA-DRB1 * 03 : 01 ( OR = 1 . 27; p<10 − 11 ); and for HLA-A*02 : 01 ( OR = 0 . 69; p<10 − 53 ).