No significant variation of PCI ST has been observed during propofol anesthesia (Friedman test, p = 0.782), but a dim variation seemed to be present during wakefulness even if it did not reach statistical significance (Friedman test, p = 0.0503).
We then identified a highly significant positive correlation between mean CD (0.18–0.3 s) across channels and PCI ST (0.08–0.6 s) , thus revealing a connection between functional connectivity and perturbational complexity (linear fit, p = 5.197 × 10 −10 , R 2 = 0.683; Fig. 5 D ). 10.1523/ENEURO.0343-20.2021.f5-1 Extended Data Figure 5-1 Functional connectivity after cortical perturbation during sevoflurane anesthesia.