a significant trendp = 0.02
Notwithstanding the small number of cases (10 HD-MTX and 10 IT-chemo), we observed a significant trend in improved survival in the HD-MTX group compared to IT-chemo only group (median OS: 28 months in IT-chemo and unreached in HD-MTX; p = 0.02; Fig. 4 D). 5.