Identifying nootropic drug targets via large-scale cognitive GWAS and transcriptomics.

Gene set results derived from the MAGMA gene-based results were highly consistent with findings of previous cognitive GWAS: gene sets that have been associated with neuropsychiatric disorders such as schizophrenia and ASD were highly significant, congruent with significant genetic correlations between GCA and these disorders.

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Genes surviving multiple testing correction in the gene-mapping analysis and nominally significant genes that were part of significant gene sets were selected for downstream drug-gene annotations.

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