Human surrogate models of central sensitization: A critical review and practical guide.

Gabapentin decreased 2HA in two controlled studies (Dirks et al., 2002 ; Petersen et al., 2014 ) and showed a trend in a third one ( p =.06; Werner et al., 2001 ).

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Taken together, hypersensitivity from capsaicin , heat‐injury and LFS models responded to drugs clinically accepted for neuropathic pain (gabapentin/pregabalin, iv ketamine, iv lidocaine) in a greater proportion than to drugs with non‐clinical effect in NP, the difference being highly significant (see Table 6 ). 4.2.2.

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