β-Cell pre-mir-21 induces dysfunction and loss of cellular identity by targeting transforming growth factor beta 2 (Tgfb2) and Smad family member 2 (Smad2) mRNAs.

To test if observed effects of miR-21 overexpression on β-cell function were associated with an increase in protein levels of β-cell progenitors, we performed immunostaining for the β-cell progenitor marker L-myc ( Figure 2 G), which showed a trend towards increased nuclear expression in INS1-miR-21 cells as compared to scramble control cells.

also in 53,322 other papers