Barely Significant
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Novel molecular targeted therapies for patients with neurofibromatosis type 1 with inoperable plexiform neurofibromas: a comprehensive review.

ESMO Open · 2021 · PMC8363824 · PMID 34388689

Europe PMCDOI
1
hedged sentence
0.0800
closest p · 1.6× alpha
0.0800
boldest claim

The sentences

did not reach statistical significanceP = 0.08so close (0.05 < p ≤ 0.1)
An association that did not reach statistical significance was observed between clinical response and an increase in sAXL ( P = 0.08), a soluble form of AXL that negatively regulates ALX signaling by binding to GAS6. 55 Some preclinical studies in NF1-deficient malignant peripheral nerve sheath tumors suggest that combination strategies of MEK inhibitors with MET or SHP2 inhibitors may overcome tumor resistance.

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