However, most studies examining the adjuvant use of bisphosphonates did not reach their endpoint despite a positive trend and a positive meta-analysis [ 21 ].
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The sentences
Note that the TTPBM analysis in subgroups is not presented due to the small number of bone metastases occurred as first event. Prognostic role of TGIF is independent of ibandronate treatment Considering treatment with ibandronate, the prognostic value of moderate/strong TGIF expression did not reach statistical significance for DFS and OS but showed a tendency towards improved survival in the individual groups with or without ibandronate treatment: In patients with ibandronate the HR for DFS was 0.79 (95%CI 0.59–1.07; log-rank p = 0.131) and for OS 0.72 (95%CI 0.49–1.06; log-rank p = 0.094).