Chaotropic and Kosmotropic Anions Regulate the Outcome of Enzyme-Mediated Dynamic Combinatorial Libraries of Cyclodextrins in Two Different Ways.

With the chaotropic anions ClO 4 − and SCN − ( Table 1 , entries 15–20) this retardation was quite significant at 1–2 M concentrations, and at concentrations of 3 M and higher, the activity of the enzyme was zero or close to zero within just 30 min of being exposed to the salt solutions ( Supplementary Figure 8 ), presumably due to denaturation of the enzyme under these conditions.

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