Intron 4-5 hTERT DNA Hypermethylation in Merkel Cell Carcinoma: Frequency, Association with Other Clinico-pathological Features and Prognostic Relevance.

In the multivariable model, we found that only m hTERT high and p63 affected OS, with marginal significance for angioinvasion and absence of MCPyV.

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MFP automatically performs backward selection by removing the weakly significant predictors and identifies the most appropriate functional form of the relationships between the outcome and the continuous covariates, thus improving model accuracy [ 46 ].

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