Metformin treatment for 8 days impacts multiple intestinal parameters in high-fat high-sucrose fed mice.

The administration of metformin was able to counteract these alterations, as reflected by the maintenance of normal body weight gain (mean gain of 0.1 ± 0.1 g) and the preservation of glucose tolerance, although the effect of metformin on fasting glucose levels did not reach statistical significance (Fig. 1 ).

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