Extracellular Matrix Protein Ratios in the Human Heart and Vessels: How to Distinguish Pathological From Physiological Changes?

Front Physiol · 2021 · PMC8371527 · PMID 34421650

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a decreasing trendno p-value reported

A decreasing trend in the ELN/COL ratio in 137 ascending aortas, from 1.65 in ages 0–20 to 1.15 in ages 70–100 was observed in another study using hot alkali extraction for elastin and hydroxyproline analysis for collagen.

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a clear trendno p-value reported

Dilated Cardiomyopathy End-stage dilated cardiomyopathy (DCM) shows a clear trend toward elevated COL1 in the heart.

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