Interestingly, some cargoes of EVs show an increasing trend in OA chondrocytes.
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Diagnostic and Therapeutic Role of Extracellular Vesicles in Articular Cartilage Lesions and Degenerative Joint Diseases.
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showed a trend for MVs to exert a better anti-inflammatory effect than exosomes and attributed this to the overexpression of anti-inflammatory protein annexin A1 (AnxA1) (Tofino-Vian et al., 2018 ).