Furthermore, the frequency of virtual platform crossing was decreased, and the time to the target quadrant was increased in App NL−F/NL−F mice fed an HFD compared to all other groups; however, the differences did not reach statistical significance (Figure S2 a,b).
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A high-fat diet exacerbates the Alzheimer's disease pathology in the hippocampus of the App<sup>NL-F/NL-F</sup> knock-in mouse model.
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