Susceptibility loci and polygenic architecture highlight population specific and common genetic features in inguinal hernias: genetics in inguinal hernias.

Genes with nominally significant cis–SNP-heritability were used to train TWAS prediction models.

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We tested pathway analysis by Pascal in order to evaluate disease-associated pathways driven by polygenic components, [ 45 ] resulting in a possibly significant signal of the focal adhesion pathway (p-value of 1•7 × 10 −4 , Supplemental Table 2).

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