Host genetic diversity drives variable central nervous system lesion distribution in chronic phase of Theiler's Murine Encephalomyelitis Virus (TMEV) infection.

PLoS One · 2021 · PMC8378701 · PMID 34415947

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hedged sentences

0.0700

closest p · 1.4× alpha

0.1000

boldest claim

The sentences

a trend towards significancep = 0.07so close (0.05 < p ≤ 0.1)

For brain level C, we detected a significant association with paresis (ANOVA; p = 0.04) and seizures (p = 0.02; CC002, p = 0.07), and a trend towards significance for CC057 (ANOVA; encephalitis, p = 0.07).

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marginally significantp = 0.08so close (0.05 < p ≤ 0.1)

We identified a marginally significant association between lesions located at brain level A and ruffling observed over 90dpi (ANOVA; p = 0.08 overall; CC027, p = 0.06).

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near-significantp = 0.10so close (0.05 < p ≤ 0.1)

However, for lesions at brain level C, we observed a significant relationship with seizures (ANOVA; p = 0.002; strain CC002, p = 0.07) and limb clasping in CC057 mice (p = 0.01), plus near-significant associations with progression scores for paresis (ANOVA; p = 0.10) and encephalitis (strain CC057, p = 0.07).

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highly significantno p-value reported

The associated SNP on chromosome 13 was highly significant.

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