Conformational distortions induced by periodically recurring A…A in d(CAG).d(CAG) provide stereochemical rationale for the trapping of MSH2.MSH3 in polyQ disorders.

Although one can envisage that the occurrence of any non-canonical base pair in the midst of the canonical base pairs may lead to conformational distortions, earlier NMR [37] , [38] , [39] and recent molecular dynamics simulation [15] , [24] , [26] , [27] studies have indicated that the conformational distortions are quite significant in the case of an A...A mismatch.

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