Type 2 diabetes mellitus duration and obesity alter the efficacy of autologously transplanted bone marrow-derived mesenchymal stem/stromal cells.

The baseline C‐peptide levels were relatively low compared with the normal range and regardless of the duration of T2DM and the patients' BMI, and a decreasing trend in the levels of C‐peptide was observed after administration, particularly in patients with a T2DM history of 10 years ( P < .07; Table 2 ).

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3.5 T2DM alters the metabolic profile of BM‐MSCs The “Cell Energy Phenotype Test” results revealed decreases in the baseline extracellular acidification rate (ECAR) and oxygen consumption rate (OCR) in both the control and T2DM groups, but these differences did not reach statistical significance (Figure 3A ).

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