Severe deficiency of the voltage-gated sodium channel Na_V1.2 elevates neuronal excitability in adult mice.

This reduction of Na V 1.6 did not reach statistical significance (91.4% ± 2.3% of WT, n = 4, p = 0.39) by qPCR validation ( Figure S4A ), indicating that our observed neuronal hyperexcitability is unlikely to result from a compensatory change of Na V 1.6 channel expression.

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