The Importance of Appropriate Dosing of Nonvitamin K Antagonist Oral Anticoagulants for Stroke Prevention in Patients with Atrial Fibrillation.

77 and 76 years, respectively). 18 Additionally, a 50% dose reduction of NOACs in patients with a CrCl >50 mL/min is more likely to result in insufficient drug exposure compared with a 25% dose reduction. These findings were similar to those from a Danish national cohort study, which showed a trend toward a higher risk of stroke/SE with the reduced dose of apixaban (4.8%), and a trend toward a lower risk of stroke/SE with the lower dose of dabigatran (3.3%) and rivaroxaban (3.5%), compared with warfarin (3.7%) at 1-year follow-up.

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