There were increases in uAGT by the 2nd and 4th week of the treatment period compared to the basal values in all strains of mice though the increases in TNFR2KO mice at 4th week (8 ± 7 to 65 ± 44 ng/24 h, p = 0.11) did not reach statistical significance level due to high variability in the results.
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Angiotensin II-induced renal angiotensinogen formation is enhanced in mice lacking tumor necrosis factor-alpha type 1 receptor.
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