near-significantp = 0.063
We found that variable G4 regions were enriched at strong enhancers as compared to stable G4 regions ( p = 0.011, Fig 5D ), and we also found a near-significant enrichment at insulator regions ( p = 0.063, Fig 5D ) in agreement with previous studies showing enrichment near CTCF at 3D domain (topologically associating domain, TAD) borders [ 37 ].