Across all seasons and for both outcomes, SD-quadrivalent was associated with a higher risk than HD-trivalent, even if the corresponding adjusted hazard ratios (aHRs) were only marginally significant for hospitalized/ER visit pneumonia (aHR 1.14, 95% confidence interval (95% CI) 1.05–1.24 for hospitalized/ER visit influenza; aHR 1.04, 1.01–1.07 for hospitalized/ER visit pneumonia) (Table 2 ).
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Relative effectiveness of influenza vaccines in elderly persons in the United States, 2012/2013-2017/2018 seasons.
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