Bisphosphonates and breast cancer survival: a meta-analysis and trial sequential analysis of 81508 participants from 23 prospective epidemiological studies.

Interestingly, meta-regression analyses revealed a borderline significant correlation between the reported effect sizes and the proportion of postmenopausal women in individual studies (slope=-0.543, P =0.057; Figure 5C ), suggesting a trend between a stronger beneficial effect with an increasing number of postmenopausal women enrolled in the original trials.

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For subgroups of post-treatment 3-4 or >4 years, TSA-corrected effects did not reach statistical significance, although the cumulative z curve for the later subgroup crossed the conventional boundary.

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