Structural and Functional Alterations in Mitochondria-Associated Membranes (MAMs) and in Mitochondria Activate Stress Response Mechanisms in an In Vitro Model of Alzheimer's Disease.

Our results obtained in APPswe cells show an impairment in mitochondrial dynamics due to an unbalance between fusion and fission, particularly in MFN2 levels ( Figure 4 a–e), as well as a slight increase in mitochondrial biogenesis ( Figure 4 f–h) that did not reach statistical significance, which could represent an attempt to improve mitochondrial metabolic capacity reducing the cascade of deleterious events caused by mitochondrial dysfunction.

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