Notably, the authors demonstrated not only a significant downregulation of the molecule in the former group ( p < 0.001), as expected, but also an association of its expression with tumor stage (stage I-II: 0.425 ± 0.033; stage III-IV: 0.128 ± 0.016, p < 0.001) and two-year survival probability, although such a correlation did not reach statistical significance [ 69 ].
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