Dual Activation of Phosphodiesterase 3 and 4 Regulates Basal Cardiac Pacemaker Function and Beyond.

Int J Mol Sci · 2021 · PMC8395138 · PMID 34445119

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did not reach statistical significanceno p-value reported

Inhibition of PDE3 alone increased DD rate and spontaneous firing of rabbit SANC by ~30% and ~20% ( p < 0.05) respectively, while effects of PDE4 inhibitor rolipram on both parameters did not reach statistical significance ( Figure 4 C,D).

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