A Mediation Approach to Discovering Causal Relationships between the Metabolome and DNA Methylation in Type 1 Diabetes.

Metabolites · 2021 · PMC8399445 · PMID 34436483

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nominally significantno p-value reported

We previously discovered nominally significant positive associations between histidine and the risk of progression from IA to T1D [ 20 ], and other studies indicated that the histidine–glutamate–glutamine pathway can be corrected by improving glycemic control [ 21 ].

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