did not reach statistical significancep < 0.00001
Although, individually, 5 studies data did not reach statistical significance [ 63 , 80 , 87 , 88 , 99 ], the overall effect showed the reduction of CRP levels after supplementation (MD: −1.10, 95% CI: −1.26, −0.93, p < 0.00001, Figure 13 ).