Pro-inflammatory T helper 17 directly harms oligodendrocytes in neuroinflammation.

Importantly, using human oligodendrocytes in primary culture, we were able to confirm that CD29 neutralization on Th17-polarized cells before 12 h coculture is protective, while CD29 activation showed a trend of increased Th17 cell toxicity toward oligodendrocyte cell processes and decreased the number of remaining oligodendrocytes ( Fig. 7 D and E and SI Appendix , Fig.

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