Collagen V insufficiency in a mouse model for Ehlers Danlos-syndrome affects viscoelastic biomechanical properties explaining thin and brittle corneas.

Interestingly, and similar to OCE measurements, Col5a1 +/− corneas showed a trend towards a steeper stress–strain curve and thus higher E-modulus than wt corneas (30.7 ± 12.1 kPa vs 21.5 ± 5.7), even though statistical significance was not reached (p = 0.057).

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