At this timepoint, there was no statistically significant increase in TGF‐β1 or TGF‐β2 in the fractionated treatment F‐sEVs group relative to the Vehicle group (Figure 4 g, h ), although TGF‐β levels showed a trend towards an increase at this time.
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Small extracellular vesicles released by infused mesenchymal stromal cells target M2 macrophages and promote TGF-β upregulation, microvascular stabilization and functional recovery in a rodent model of severe spinal cord injury.
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