Risk factors and disease profile of post-vaccination SARS-CoV-2 infection in UK users of the COVID Symptom Study app: a prospective, community-based, nested, case-control study.

40 Several other comorbidities, including heart disease and lung disease, were significantly associated with post-vaccination infection after one dose in older adults; although associations of marginal significance should be interpreted cautiously, many of these comorbidities confer a higher risk of severe disease, hospitalisation, mechanical ventilation, and mortality from COVID-19, 16 , 18 and ongoing shielding behaviours could be influencing our results to reduce the strength of these associations.

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