An X chromosome-wide meta-analysis based on Japanese cohorts revealed that non-autosomal variations are associated with serum urate.

In the meta-analysis, the rs3020789 showed a genome-wide significant association and a nominally significant association for the male group ( β = –0.020; P = 2.12 × 10 −8 ) and female group ( β = –0.012; P = 0.024).

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Although our eQTL analysis found little effect of the identified SNPs on DUSP9 levels in the kidney (possibly due to a lack of information on the kidney in GTEx), finding out how, with or without inter-organ communication, DUSP9 might be involved in renal urate handling is likely to be significant and merits further study.

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