Scn2a severe hypomorphic mutation decreases excitatory synaptic input and causes autism-associated behaviors.

JCI Insight · 2021 · PMC8410058 · PMID 34156984

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showed a trendno p-value reported

We did not observe a significant difference in frequency of sIPSCs between WT and Scn2a Δ1898/+ mice, nor a difference in Na + currents within inhibitory neurons, although the average frequency of sIPSCs showed a trend to decrease.

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