Growth Differentiation Factor 15 Is Associated With Alzheimer's Disease Risk.

Although no heterogenous variants were revealed in the scatter plot ( Figure 3 ) and leave-one-out analysis ( Figure 4 ), the causal estimates given by Wald ratios from both rs3195944 (OR = 1.25; 95% CI, 1.06–1.48; p = 0.007) and rs1227731 (OR = 1.26; 95% CI, 1.08–1.46; p = 0.003) were notably nominally significant ( p < 0.05) when examining the effect of GDF-15 on AD mediated by individual SNP ( Supplementary Table 5 ).

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