RNA sequencing of blood in coronary artery disease: involvement of regulatory T cell imbalance.

The composite score of 7 transcripts was highly significant between groups (p = 6.02 × 10 −12 ), and a simple linear prediction model yielded a receiver-operator curve (ROC, via JROCFIT [ 23 ]) with a C-statistic of 0.873, sensitivity of 77.4%, specificity of 83.7% and overall accuracy of 80.2%, with a positive predictive value (PPV) of 85.4% and negative predictive value (NPV) of 75.0% (Fig. 4 , Lower Right Panel).

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Both the Discovery and Validation DEGs (92% decreased in CAD) shared a strong trend toward decreasing expression in the CAD group.

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