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Head and neck squamous cell carcinoma cell lines have an immunomodulatory effect on macrophages independent of hypoxia and toll-like receptor 9.

BMC Cancer · 2021 · PMC8418007 · PMID 34479492

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While this result did not reach statistical significance, it was yet an interesting finding as the expression of IL-12 cytokine is NF-κB-regulated.

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