Age-dependent instability of mature neuronal fate in induced neurons from Alzheimer's patients.

iPSC-iNs showed more gene expression differences than iPSCs or fibroblasts, which did not reach statistical significance ( Figure 7 F).

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Unsurprisingly, fibroblasts did not display any significant AD-specific DE genes, whereas 778 highly significant (false discovery rate [FDR] < 0.01) DE genes were identified in iNs ( Figure 2 A; Table S3 ).

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