Monocyte-derived and M1 macrophages from ankylosing spondylitis patients released higher TNF-α and expressed more IL1B in response to BzATP than macrophages from healthy subjects.

Although BzATP significantly elevated the expression level of IL1B in monocyte-generated macrophages from both patients and controls ( P -value < 0.05 and P -value < 0.01 respectively), the elevated protein secretion of IL-1β after treatment did not reach statistical significance.

also in 111,027 other papers