Dynamic weight-bearing test during jumping: A sensitive outcome measure of chronic osteoarthritis pain in rats.

In rats that received IA Zilretta on day 7, jump incapacitance on day 15 (8 days after injection) was almost normal (96 ± 5.7%) and, in contrast to the DMM and vehicle group, was not statistically different (p = 0.45) to healthy controls (103 ± 6.7%) and almost significantly different the DMM and vehicle group (p = 0.069).

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Finally, Zilretta is approved to treat pain in knee OA and here we have demonstrated that there is a clear trend for a therapeutic benefit of Zilretta in the rat DMM model of OA.

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