PGC-1α promotes mitochondrial respiration and biogenesis during the differentiation of hiPSCs into cardiomyocytes.

Genes Dis · 2021 · PMC8427271 · PMID 34522716

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In addition, day 30-hiPSC-CMs showed a trend for increased coupling to ATP synthesis when treated with the ATP synthase inhibitor oligomycin ( Fig. 2 B), indicating that hiPSC-CMs produce ATP mainly through OXPHOS.

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