Every Night and Every Morn: Effect of Variation in <i>CLOCK</i> Gene on Depression Depends on Exposure to Early and Recent Stress.

Main Effects of Variation in CLOCK on Current Depressive Symptoms and Lifetime Depression Linear and logistic regression models on BSI-Dep (for current depression) and DEP (for lifetime depression), respectively, identified a few SNPs with a nominally significant main effect, but significant clumps could not be formed, furthermore, all p -values exceeded the maximum threshold for top SNP ( p = 0.001) [ Supplementary Tables 1 , 2 for lifetime depression (DEP) and current depressive symptoms (BSI-Dep, respectively), but significant clumps for main genetic effects could not be identified].

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